If you working with BizTalk Server 2006 R2 and there are a lot of installation (instances) globally a new SP1 is coming out soon. Beta SP1 for BizTalk Server 2006 R2 has been released today. This service pack is an update for BizTalk Server 2006 R2. It includes fixes to issues that have been reported through customer feedback platforms towards Microsoft, as well as within Microsoft discovered issues. To get hold of the beta you need to go here. A guide for this service pack is also available on the download page.